Immunological and conformational characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

G. Blessed, B. E. Tomlinson, Martin Roth · The British Journal of Psychiatry · 1968 · 4.1K citations

Medicine, Geriatric Medicine, Neurology +17

Computed circular dichroism spectra for the evaluation of protein conformation

Norma J. Greenfield, Gerald D. Fasman · Biochemistry · 1969 · 3.7K citations

Life Sciences, Biochemistry, Biophysics +17

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

Virginia M.‐Y. Lee, Brian J. Balin, László Ötvös et al. · Science · 1991 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +17

Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

Michel Goedert, Maria Grazia Spillantini, Marie‐Claude Potier et al. · The EMBO Journal · 1989 · 1K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +11

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

M.T. Kidd · Nature · 1963 · 982 citations

Life Sciences, Cell Biology, Molecular Biology +14