Cyclo (D-Pro-L-Val), a Specific .BETA.-Glucosidase Inhibitor Produced by Aspergillus sp. F70609.

Abstract

catalyze the hydrolysis of poly and oligosaccharides into monomersor cleave bonds between sugars and non-carbohydrate aglycons. Thus, a number of metabolic processes rely on these enzymes for their efficacy, selectivity and control1}. There is nowa great deal of interest in glycosidase inhibitors since these compounds have been shownto be important tools in studies on the mechanism of enzyme-catalyzed glycoside hydrolysis2), oligosaccharide structure, and in medicinal chemistry3'4).