American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 2006 · 48 citations · 28 references
Life SciencesGeneticsNeurologyGenetic EpidemiologyMedical GeneticsNeurogeneticsCytokine Gene PolymorphismDisease Susceptibility LociGenetic SusceptibilityMovement Disorder GeneticsNeurodegenerative DisordersParkinson DiseaseDisease Susceptibility AssociationGenotype DistributionHaplotype InheritanceLinkage Disequilibrium PatternsPairwise Linkage DisequilibriumParkinson's Disease GeneticsPolymorphism Linkage DisequilibriumTumor Necrosis Factor Alpha Variants
Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case-control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor-alpha (TNF-alpha) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T-1031C and C-857T sites showed significant difference between PD cases and controls (P = 0.0062 and 0.0035, respectively). However, only the more frequent -1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.96; 95% CI: 1.38-7.09). Pairwise SNP linkage disequilibrium showed -1031 and -863 sites are in strong linkage disequilibrium (D' = 0.93, Delta(2) = 0.80). Pairwise haplotype analysis among the four sites showed that -1031C-863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33-3.69).
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SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders
Irene Litvan, Kailash P. Bhatia, David J. Burn et al. · Movement Disorders · 2003 · 1K citations
Medicine, Neurology, Neuroscience +17