Basic & Clinical Pharmacology & Toxicology · 2011 · 26 citations · 37 references
MedicineNeurosciencePharmacologyCardiovascular PharmacotherapyClinical PharmacologyNeuropharmacologyAcute Ischemic StrokeCerebrovascular DiseaseCerebrovascular PhysiologyNeuroprotectionStrokeStroke PharmacotherapyAcute Ischemic Stroke TreatmentBone Marrow - Derived CellsBone Marrow Mesenchymal Stem CellsBone Marrow-derived Mesenchymal Stromal CellsFunctional Outcome EvaluationFunctional Outcome MeasurementRodent Cerebral IschemiaStroke Models
In this study, we investigated the therapeutic effects of simvastatin administered in combination with bone marrow stromal cells (BMSCs) following experimentally induced embolic stroke in rats. Effects on infarct volume, brain oedema and neurological deficits were examined. Focal ischaemic brain injury was induced by emblazing a preformed clot into the middle cerebral artery in rats. Animals were administered simvastatin (40 mg/kg) at 1 hr after stroke, or BMSCs (3 × 10(6)) at 24 hr after stroke or a combination of these two treatments. Rats receiving a dose of simvastatin in combination with BMSC administration demonstrated a significant reduction in neurological deficits, a significant reduction in infarct volume and a significant decrease in brain oedema. Our data show that combining simvastatin administration with BMSCs has an additive effect on improving functional outcome in this thromboembolic stroke model.
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A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs
Mihaela Crisan, Solomon Yap, Louis Casteilla et al. · Cell stem cell · 2008 · 4K citations · Full text
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C-Reactive Protein Levels and Outcomes after Statin Therapy
Paul M. Ridker, Christopher P. Cannon, David A. Morrow et al. · New England Journal of Medicine · 2005 · 2.3K citations · Full text
Jieli Chen, Yi Li, Lei Wang et al. · Stroke · 2001 · 1.8K citations · Full text
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