Fragment Condensation of C‐Terminal Pseudoproline Peptides without Racemization on the Solid Phase

Abstract

Hot couplings without racemization: Protected peptides featuring C-terminal pseudoprolines were synthesized on a solid support, and these versatile building blocks were used in convergent peptide-segment couplings, which proceeded without racemization even under microwave conditions. The solubility-enhancing effect of pseudoproline residues facilitated the synthesis of complex RNase 39-mer glycopeptide thioesters.