Impairment of debrisoquine 4-hydroxylase and related monooxygenase activities in the rat following treatment with propranolol

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

A. Mahgoub, L. G. Dring, Jeffrey R. Idle et al. · The Lancet · 1977 · 1.2K citations

Pharmacy, Biochemistry, Pharmacology +6

MEDICAL NEMESIS

George Discombe · The Lancet · 1974 · 377 citations

Humanities, Internal Medicine, Clinical Medicine +1

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

A. K�pfer, R Preisig · European Journal of Clinical Pharmacology · 1984 · 364 citations

Veterinary Medicine, Genetics, Pharmacology +10

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

Stephen A. Ward, Thomas Walle, U. Kristina Walle et al. · Clinical Pharmacology & Therapeutics · 1989 · 175 citations

Medicine, Pharmacokinetics, Pharmacology +17