Curcumin Induces Cell Death in Esophageal Cancer Cells through Modulating Notch Signaling

Abstract

Curcumin is a potent inhibitor of esophageal cancer growth that targets the Notch-1 activating γ-secretase complex proteins. These data suggest that Notch signaling inhibition is a novel mechanism of action for curcumin during therapeutic intervention in esophageal cancers.