Delivery of a Normal Infant During the Course of Oral Vinblastine Sulfate Therapy for Hodgkin's Disease

Abstract

Case Studies1 July 1964Delivery of a Normal Infant During the Course of Oral Vinblastine Sulfate Therapy for Hodgkin's DiseaseJAMES G. ARMSTRONG, M.D., RICHARD W. DYKE, M.D., F.A.C.P., PAUL J. FOUTS, M.D., F.A.C.P., CHRISTIAN J. JANSEN, M.D.JAMES G. ARMSTRONG, M.D.Search for more papers by this author, RICHARD W. DYKE, M.D., F.A.C.P.Search for more papers by this author, PAUL J. FOUTS, M.D., F.A.C.P.Search for more papers by this author, CHRISTIAN J. JANSEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-1-106 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDerivatives from the flowering periwinkle plant (Vinca rosea Linn.) (1) have been found useful in the treatment of several types of human cancer, including Hodgkin's disease (2, 3). These drugs, vinblastine sulfate (VLB) and vincristine sulfate (VCR), were shown to have embryocidal and teratogenic effects when administered to pregnant golden hamsters (4). However, the dose of VLB or VCR that is toxic for one species will not necessarily be toxic in the same way for another species. In our laboratories, for instance, it has been found that the single intravenous median lethal dose of VLB for dogs is 0.2 mg...References1. SVOBODAJOHNSONGORMANNEUSS GHISMN: Current status of research on the alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don). J. Pharm. Sci. 51: 707, 1962. CrossrefMedlineGoogle Scholar2. ARMSTRONGDYKEFOUTSGAHIMER JGRWPJJE: Hodgkin's disease, carcinoma of the breast, and other tumors treated with vinblastine sulfate. Cancer Chemother. Rep. 18: 49, 1962. MedlineGoogle Scholar3. CARBONEBRINDLEY PPCO: Clinical studies with leurocristine. Proc. Amer. Ass. Cancer Res. 3: 360, 1962. Google Scholar4. FERM VH: Congenital malformations in hamster embryos after treatment with vinblastine and vincristine. Science. 141: 426, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, IndianaFrom the Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis, Indiana.Requests for reprints should be addressed to James G. Armstrong, M.D., Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis 7, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCancer chemotherapeutic agents as human teratogensAdverse Reproductive Outcome Potential of Cancer Therapies During PregnancyRADIATION THERAPY DURING PREGNANCYMantle irradiation for Hodgkin's disease during pregnancy: Safe and practical?Pharmacology of antineoplastic agents in pregnancyTreatment Options for Hodgkin's Disease During PregnancySuccessful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancyCytotoxic drugs in pregnancyManagement of the Pregnant Patient with Hodgkin's DiseaseCHARLOTTE JACOBS, M.D., SARAH S. DONALDSON, M.D., SAUL A. ROSENBERG, M.D., HENRY S. KAPLAN, M.D.Non-Hodgkin's lymphoma in pregnancyPregnancy outcome of patients treated for Hodgkin's disease.A controlled studyGenetic and related effects of Vinca rosea alkaloidsMultiple agent chemotherapy including bleomycin of non-hodgkin's lymphoma during pregnancyToxicity of Antineoplastic Agents in Man: Chromosomal Aberrations, Antifertility Effects, Congenital Malformations, and Carcinogenic PotentialImmunosuppressive and Cytotoxic Chemotherapy: Long-Term ComplicationsPHILIP S. SCHEIN, M.D., F.A.C.P., M.R.C.P., STANLEY H. WINOKUR, M.D.Teratogenic Effects of Combination ChemotherapyM. J. GARRETT, M.D., F.F.R.Combination chemotherapy in malignant diseaseBiological Activity of the Terpenoids and Their Derivatives — Recent AdvancesDiagnosis and Therapy of Malignant Lymphoma during PregnancySevere Vinblastine-Induced Leukopenia During Late Pregnancy with Delivery of a Normal InfantJAMES J. NORDLUND, M.D., VINCENT T. DEVITA, M.D., PAUL P. CABBONE, M.D.CYTOTOXIC DRUGS IN PREGNANCY. Review of Reported CasesThe Response of Hodgkin's Disease to Treatment with Oral Vinblastine SulfateHENRY E. WILSON, M.D., F.A.C.P., JOHN LOUIS, M.D., F.A.C.P.SPECIAL PROBLEMS IN TOXICITYA Methylhydrazine Derivative in Hodgkin's Disease and Other Malignant Neoplasms Therapeutic and Toxic Effects Studied in 51 PatientsKURT W. BRUNNER, M.D., CHARLES W. YOUNG, M.D.Use of Vinblastine Sulfate to Treat Hodgkin's Disease During PregnancyMORTIMER J. LACHER, M.D. 1 July 1964Volume 61, Issue 1Page: 106-107KeywordsCancer treatmentClinical laboratoriesDrugsHodgkin lymphomaInfantsMedian lethal dosePregnancyResearch laboratoriesSulfates Issue Published: 1 July 1964 PDF DownloadLoading ...