Science · 1978 · 217 citations · 24 references
Life SciencesMedicinal ChemistryMicrobiologyMolecular VirologyVirologyAntiviral AgentsAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyViral InfectionsAntiviral Drug DesignAntiviral TherapeuticsAntiviral TreatmentHerpesvirus Antiviral TherapyInfectious Bovine RhinotracheitisTreatment Of Herpesvirus InfectionsViral Polymerase Inhibitors
Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.
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