Concepedia

Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo

Stephen B. Williams, Allison B. Goldfine, Farris K. Timimi, Henry H. Ting, Mary-Anne Roddy, Donald C. Simonson, Mark A. Creager

Circulation · 1998 · 793 citations · 52 references

DOIFull text

Open access

Abstract

Acute hyperglycemia impairs endothelium-dependent vasodilation in healthy humans in vivo. This finding suggests that elevated glucose may contribute to the endothelial dysfunction observed in patients with diabetes mellitus.

References

52

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

New England Journal of Medicine · 1993 · 24.5K citations · Full text

Nitric oxide: an endogenous modulator of leukocyte adhesion.

Paul Kubes, Motohisa Suzuki, D. Neil Granger · Proceedings of the National Academy of Sciences · 1991 · 3K citations · Full text

, , +17

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

Ryszard J. Gryglewski, Richard Palmer, Salvador Moncada · Nature · 1986 · 2.4K citations

, , +12

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

Uttam Garg, Aviv Hassid · Journal of Clinical Investigation · 1989 · 2.2K citations · Full text

, , +16

Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes

Simon P. Wolff, Roger T. Dean · Biochemical Journal · 1987 · 1.3K citations · Full text