Hypotensive and renovascular actions of 6-keto-prostaglandin E1, a metabolite of prostacyclin

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

Stuart Bunting, Salvador Moncada, John R. Vane et al. · Prostaglandins · 1976 · 955 citations

Medicine, Physiology, Signal Transduction +11

The chemical structure of prostaglandin X (prostacyclin)

Roy A. Johnson, Douglas R. Morton, John H. Kinner et al. · Prostaglandins · 1976 · 730 citations

Natural Sciences, Chemistry, Pharmacology +10

COMPARISON OF THE VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6‐OXO‐PROSTAGLANDIN F_1α WITH THOSE OF PROSTAGLANDIN E₂ IN RATS AND RABBITS

J. M. Armstrong, Norman Lattimer, Salvador Moncada et al. · British Journal of Pharmacology · 1978 · 278 citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +10

Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney.

Kafait U. Malik, J C McGiff · Circulation Research · 1975 · 223 citations · Full text

Life Sciences, Pharmacology, Physiology +15

Hepatic metabolism of prostacyclin (PGI2) in the rabbit: Formation of a potent novel inhibitor of platelet aggregation

Patrick Y.-K. Wong, Kafait U. Malik, Dominic M. Desiderio et al. · Biochemical and Biophysical Research Communications · 1980 · 106 citations

Medicine, Biochemistry, Pharmacology +13