European Journal of Biochemistry · 1979 · 162 citations · 20 references
Life SciencesBiochemistryChemistryEnzymologyStructural BiochemistryStructural BiologyCoenzyme ChemistryEnzyme BiophysicsEnzyme FunctionEnzyme StructureEnzyme-substrate RecognitionStructural EnzymologyCoenzyme BindingCoenzyme StructureEnzyme Structure-function RelationshipsSubstrate Binding Sites
The binding of Cibacron F3GA to orthorhombic crystals of liver alcohol dehydrogenase has been studied to 0.37-nm resolution. Similarities in the binding of this dye were found for rings B, C and D with the binding of the coenzyme NAD+. However, ring A of the dye and the nicotinamide ribose part of the coenzyme are quite differently bound to the enzyme.
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Substrate positions and induced-fit in crystalline adenylate kinase
E.F. Pai, W. Sachsenheimer, R. Heiner Schirmer et al. · Journal of Molecular Biology · 1977 · 302 citations