Journal of Polymer Science Part A Polymer Chemistry · 2011 · 39 citations · 43 references
PharmacyBioengineeringPharmaceuticsDrug DeliveryNanoparticle Drug DeliveryTargeted Drug DeliveryControlled Release MechanismsDrug Delivery SystemsDrug EncapsulationMagnetic-responsive Drug DeliveryNanoparticle Delivery SystemsPh-responsive Drug DeliveryHybrid Drug Delivery SystemsIron Oxide NanoparticlesMagnetic Drug Delivery SystemsMagnetic Drug ReleaseMagnetic Nanoparticle Drug CarriersMagnetic Nanoparticle Drug DeliveryMagnetic Oxide NanoparticlesNanocarrier Encapsulation Efficiency
Abstract Novel magnetic‐targeted pH‐responsive drug delivery system have been designed by the layer‐by‐layer self‐ assembly of the polyelectrolytes (oligochitosan as the polycation and sodium alginate as the polyanion) via the electrostatic interaction with the oil‐in‐water type hybrid emulsion droplets containing the superparamagnetic ferroferric oxide nanoparticles and drug molecules [dipyridamole (DIP)] as cores. Here the drug molecules were directly encapsulated into the interior of droplets without etching the templates and refilling with the desired guest molecules. The drug‐delivery system showed high encapsulation efficiency of drugs and drug‐loading capacity. The cumulative release ratio of dipyridamole from the oligochitosan/sodium alginate multilayer‐encapsulated magnetic hybrid emulsion droplets (DIP/Fe 3 O 4 ‐OA/OA)@(OCS/SAL) 4 was up to almost 100% after 31 h at pH 1.8. However, the cumulative release ratio was only 3.3% at pH 7.4 even after 48 h. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
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Laser‐Induced Release of Encapsulated Materials inside Living Cells
André G. Skirtach, Oliver Kreft, Karen Köhler et al. · Angewandte Chemie · 2006 · 455 citations