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Studies of Rhodium(II) Carboxylates as Potential Antitumor Agents
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1974
Year
Chemical BiologyPharmaceutical ChemistryRedox BiologyMedicinal ChemistryBiosynthesisNucleic Acid ChemistryRna SynthesisNatural Product BiosynthesisAnti-cancer AgentPotential Antitumor AgentsBiochemistryPurine BiosynthesisPharmacologyNatural Product SynthesisNatural SciencesNucleic Acid BiochemistryCarbon-14-labeled RhodiumMedicineDrug Discovery
SummaryRhodium (II) acetate and rhodium (II) propionate were found to be antineoplastic agents. Both compounds inhibited DNA and RNA synthesis. The rhodium(II) propionate was also found to block de novo purine biosynthesis. Binding studies employing the carbon-14-labeled rhodium (II) acetate showed binding to DNA (poly A), and two proteins.