Experimental Biology and Medicine · 1974 · 136 citations · 0 references
MedicineOncologyPharmacologyCancer PharmacologyMolecular OncologyMolecular PharmacologyEnzyme InhibitionOncology PharmacologyRibonucleic Acid (Rna) ChemistryAnticancer ActivityAntineoplastic Drug TherapyBinding StudiesCompetitive Binding StudiesPurine BiosynthesisPurine Chemistry
Rhodium (II) acetate and rhodium (II) propionate were found to be antineoplastic agents. Both compounds inhibited DNA and RNA synthesis. The rhodium(II) propionate was also found to block de novo purine biosynthesis. Binding studies employing the carbon-14-labeled rhodium (II) acetate showed binding to DNA (poly A), and two proteins.