Role of elevated platelet‐associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases

Abstract

Serum TPO level may not be directly associated with thrombocytopenia in patients with chronic hepatitis and liver cirrhosis. In contrast, spleen volume and PAIgG are associated with thrombocytopenia in such patients, suggesting that hypersplenism and immune-mediated processes are predominant thrombocytopenic mechanisms.