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PROLONGATION OF ALLOGRAFT SURVIVAL IN MICE BY INDUCERS OF INTERFERON
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1973
Year
Newcastle Disease VirusImmunologyViral PathogenesisTissue TransplantationImmunotherapyDrinking WaterGraft SurvivalImmunopathologyCell TransplantationKnockout MouseXenotransplantationAutoimmune DiseaseTransplantationAllergyVirologyAutoimmunityCell BiologyAntiviral ResponseProlonged SurvivalVirus-host InteractionMedicineGraft Rejection
Three different types of agents known to induce interferon in mice significantly prolonged the survival of mouse tail skin allografts made across H-2 differences. Newcastle disease virus given i.v. on the day of or the day after grafting prolonged survival by 1.7 and 3.5 days, respectively. Statolon, a double stranded RNA mycophage, given i.p. in three doses of 3 mg each on the day of and the 2nd and 5th days after grafting prolonged survival by 1.9 days. Tilorone hydrochloride, in a concentration of 0.3 mg/ml given continuously by means of the drinking water, prolonged allograft survival by 4.7 days. These results are consistent with the idea that interferon inhibits the cellular immune response to allografts.