Acta Crystallographica Section A Foundations of Crystallography · 2005 · 15 citations · 0 references
Life SciencesBiochemistryMicrobiologyEnzymologySignal TransductionStructural BiologyAllosteric RegulationBacterial Cell StructureBacterial Gene RegulationCyclic Nucleotide SignalingAdenylate Cyclase RegulationAllosteric Control Of CatalysisCyclic Nucleotide Binding ProteinsCyclic Nucleotide SynthesisNucleotide Binding DomainsSecond Messenger TransferSequence Motif ConservationSignal Transduction By Cyclic Nucleotides
Recent studies suggest that a novel second messenger, cyclic d-GMP (c-diGMP), is extensively used by bacteria to control multicellular behaviour. This cyclic dinucleotide is synthesised by the diguanylate cyclase (DGC) domain in a reaction that converts two GTP into one c-diGMP and two pyrophosphates. The DGC domain contains a highly conserved GG(D/E)EF sequence motif, and occurs in various combinations with sensory / regulatory domains in bacteria.