G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: The role of type 2 diabetes and fatty acids

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Yasuaki Itoh, Yuji Kawamata, Masataka Harada et al. · Nature · 2003 · 1.5K citations

Life Sciences, Cell Biology, Endocrinology +16

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

Valeriya Lyssenko, R Lupi, Piero Marchetti et al. · Journal of Clinical Investigation · 2007 · 831 citations · Full text

Medicine, Endocrinology, Genetics +17

Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets

R Lupi, Francesco Dotta, Lorella Marselli et al. · Diabetes · 2002 · 602 citations · Full text

Life Sciences, Cell Biology, Endocrinology +17

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

Pär Steneberg, Nir Rubins, Reut Bartoov-Shifman et al. · Cell Metabolism · 2005 · 414 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +16

Role of GPR40 in fatty acid action on the β cell line INS-1E

Hagit Shapiro, Sigal Shachar, Israel Sekler et al. · Biochemical and Biophysical Research Communications · 2005 · 222 citations

Life Sciences, Cell Biology, Molecular Biology +12