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Antagonism of luteinizing hormone release and of ovulation by an analog of the luteinizing hormone-releasing hormone
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1975
Year
FertilityReproductive HealthGynecology4-Day Cycling RatReproductive BiologyGastrointestinal Peptide HormoneReproductive EndocrinologyHypothalamic PeptidePublic HealthSolid-phase MethodsInfertilityGrowth HormoneBiochemistryEndocrine MechanismEndocrinologyPharmacologyHormone-releasing HormoneHormone ReleaseSignal TransductionLh-rh Induced SecretionPhysiologyReceptor BiologyMedicineReproductive HormoneNeuropeptides
Two varients of LH-RH, less than Glu-D-Phe-Trp-D-Ala-Leu-Arg-Pro-Gly-NH2 (I) and less than Glu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHCH2CH3 (II), have been synthesized by solid-phase methods. Both peptides strongly inhibit the LH-RH induced secretion of LH in an in vitro assay; however, only I proved effective in preventing ovulation in the 4-day cycling rat.