Concepedia

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

Michael R. Lieber, Joanne E. Hesse, Susanna M. Lewis, Gayle C. Bosma, Naomi Rosenberg, Kiyoshi Mizuuchi, Melvin J. Bosma, Martin Gellert

Cell · 1988 · 435 citations · 19 references

Concepts

Life SciencesGeneticsImmunologyImmunogeneticsImmunopathologyRecombinationCombined ImmunodeficiencyImmunodeficiency DisordersImmunoglobulin Gene RearrangementPrimary ImmunodeficiencyRecombination ProteinsV(d)j RecombinationJoining Gene SegmentsRecombination Signal Sequence RecognitionRecombination Signal SequencesV(d)j Recombination DefectsV(d)j Recombination MachineryV(d)j Recombination MechanismV(d)j Recombination Regulation

References

19

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

Jeffrey Vieira, Joachim Messing · Gene · 1982 · 6.1K citations

Life Sciences, Genetics, Molecular Biology +15

A severe combined immunodeficiency mutation in the mouse

Gayle C. Bosma, R. Philip Custer, Melvin J. Bosma · Nature · 1983 · 2.2K citations

Life Sciences, Genetics, Immunology +12

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

C M Gorman, Glenn Merlino, Mark C. Willingham et al. · Proceedings of the National Academy of Sciences · 1982 · 1.4K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +15

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

W. Schüler, Ivan Jeanne Weiler, Amelie Schuler et al. · Cell · 1986 · 550 citations

Life Sciences, Genetics, Immunology +11

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

David B. Roth, John H. Wilson · Molecular and Cellular Biology · 1986 · 459 citations

Life Sciences, Genetics, Molecular Biology +11