Concepedia

Discovery and synthesis of a new class of opioid ligand having a 3-azabicyclo[3.1.0]hexane core. An example of a ‘magic methyl’ giving a 35-fold improvement in binding

Graham Lunn, B. J. BANKS, Robert Crook, N. Feeder, Alan Pettman, Yogesh Sabnis

Bioorganic & Medicinal Chemistry Letters · 2011 · 31 citations · 4 references

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4

The maximal affinity of ligands

Irwin D. Kuntz, K. Chen, Kim A. Sharp et al. · Proceedings of the National Academy of Sciences · 1999 · 845 citations

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A controlled trial of naloxone infusions for the pruritus of chronic cholestasis

Nora V. Bergasa, Thomas Talbot, David W. Alling et al. · Gastroenterology · 1992 · 289 citations · Full text

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Efficacy and safety of naltrexone, an oral opiate receptor antagonist, in the treatment of pruritus in internal and dermatological diseases

Dieter Metze, Sonja Reimann, Stefan Beissert et al. · Journal of the American Academy of Dermatology · 1999 · 161 citations

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Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors

Dennis M. Zimmerman, J. David Leander, Buddy E. Cantrell et al. · Journal of Medicinal Chemistry · 1993 · 60 citations · Full text

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