Selective inhibition of Δ-6 desaturase impedes intestinal tumorigenesis

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

Masanobu Oshima, Joseph Dinchuk, Stacia Kargman et al. · Cell · 1996 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Genetics +16

Cloning, Expression, and Nutritional Regulation of the Mammalian Δ-6 Desaturase

Hyekyung P. Cho, Manabu Nakamura, Steven D. Clarke · Journal of Biological Chemistry · 1999 · 624 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.

Patricia C. Chulada, Morrow B. Thompson, Joel F. Mahler et al. · PubMed · 2000 · 498 citations

Medicine, Molecular Biology, Oncology +13

The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.

Russell F. Jacoby, Karen Seibert, Carolyn E. Cole et al. · PubMed · 2000 · 483 citations

Medicine, Pharmacology, Pharmacotherapy +14

Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.

Kouji Watanabe, Toshihiko Kawamori, Seiichi Nakatsugi et al. · PubMed · 1999 · 358 citations

Medicine, Oncology, Pharmacology +12