The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.

Russell F. Jacoby, Karen Seibert, Carolyn E. Cole, +2

PubMed

Chemoprevention StrategyTherapeutic Target Cox-2ApoptosisCell DeathPathology +18

MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability

Steven M. Lipkin, Victoria Wang, Russell F. Jacoby, +5

Nature Genetics

Genome InstabilityGenetic DisorderGeneticsMolecular GeneticsMammalian Microsatellite Instability +3

Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam.

Russell F. Jacoby, D. J. Marshall, Michael A. Newton, +8

PubMed

InflammationTumor BiologyOncologyOncogenic AgentGastrointestinal Pharmacology +13

Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.

William F. Dove, Linda Clipson, Karen A. Gould, +5

PubMed

DysbiosisMucosal ImmunologyPathogenesisImmunologyGastroenterology +13

Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos.

Russell F. Jacoby, Carolyn E. Cole, Kendra D. Tutsch, +4

PubMed

Tumor BiologyChemoprevention StrategySelective Cox-2 InhibitionGastrointestinal OncologyMedicine +12

Tumorigenesis in the multiple intestinal neoplasia mouse: Redundancy of negative regulators and specificity of modifiers

Richard B. Halberg, Darren S. Katzung, Peter D. Hoff, +6

Proceedings of the National Academy of Sciences

Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.

Russell F. Jacoby, Xavier Llor, Ba-Bie Teng, +2

Journal of Clinical Investigation

Colon CarcinogenesisCarcinogen InjectionsOncogenic AgentGastrointestinal PharmacologyK-ras Oncogene +10

K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.

Xavier Llor, Russell F. Jacoby, Ba‐Bie Teng, +3

PubMed

NutritionSupplemental Dietary CalciumVitamin D-sufficientOncologyChemoprevention Strategy +13

Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer

Russell F. Jacoby, David J. Marshall, Sujatha Kailas, +3

Gastroenterology

Genetic InstabilityCancer PathologyMedicineGeneticsColorectal Cancer +4

Genetic Analysis of Colon Cancer Susceptibility in Mice

Russell F. Jacoby, Colleen Hohman, David J. Marshall, +5

Genomics

GeneticsGenetic EpidemiologyPathologyColorectal CancerCancer Genetics +3