Insulin Secretion, DNA Damage, and Apoptosis in Human and Rat Islets of Langerhans Following Exposure to Nitric Oxide, Peroxynitrite, and Cytokines

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Joseph S. Beckman, ThomasJ Beckman, Jake Y. Chen et al. · Proceedings of the National Academy of Sciences · 1990 · 7.1K citations

Life Sciences, Biochemistry, Cell Biology +15

Automated Method for Isolation of Human Pancreatic Islets

Camillo Ricordi, Paul E. Lacy, EDWARD H. FINKE et al. · Diabetes · 1988 · 1.3K citations

Medicine, Endocrinology, Physiology +15

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

Csaba Szabó, Basilia Zingarelli, Michael O′Connor et al. · Proceedings of the National Academy of Sciences · 1996 · 624 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Nitric Oxide Protects Cultured Rat Hepatocytes from Tumor Necrosis Factor-α-induced Apoptosis by Inducing Heat Shock Protein 70 Expression

Young‐Myeong Kim, Michael E. de Vera, Simon C. Watkins et al. · Journal of Biological Chemistry · 1997 · 525 citations · Full text

Veterinary Medicine, Pharmacology, Toxicology +16

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans.

John A. Corbett, Michael A. Sweetland, Jaw‐Lin Wang et al. · Proceedings of the National Academy of Sciences · 1993 · 409 citations

Life Sciences, Endocrinology, Immunology +17