Physicochemical Compatibility of Propofol-Lidocaine Mixture

Abstract

The addition of lidocaine to propofol results in time- and dose-dependent increases in oil droplet diameters in emulsion. This mixture is physicochemically unstable over time and may cause pulmonary embolism, depending on the dose of lidocaine.

References

Page 1

	Year	Citations
Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape Lisbeth Ilium, S.S. Davis, C G Wilson, International Journal of Pharmaceutics NanoparticlesColloidal MaterialEngineeringColloidal ParticlesHematology	1982	251
Reducing Pain During Propofol Injection Michael F. Roizen, Jens Rau, W. Kellermann, Anesthesia & Analgesia	1996	146
Clearance of 141Ce-labeled microspheres from blood and distribution in specific organs following intravenous and intraarterial administration in beagle dogs Motoko Kanke, Guy H. Simmons, Daniel L. Weiß, Journal of Pharmaceutical Sciences Animal PhysiologyVeterinary PhysiologyVeterinary PathologySpecific OrgansVeterinary Science	1980	141
Physicochemical stability of total nutrient admixtures David F. Driscoll, Hridaya N. Bhargava, Luk Li, American Journal of Health-System Pharmacy NutritionEngineeringFood AnalysisFood BiophysicsAgricultural Economics	1995	126
Effect of lignocaine and pH on propofol-induced pain Mats Eriksson, S. Englesson, Frank Niklasson, British Journal of Anaesthesia Propofol-induced PainHealth SciencesPain MedicineMedicinePain Management	1997	107
Physical properties and stability of two emulsion formulations of propofol Jihong Han, Stanley S. Davis, C. Washington International Journal of Pharmaceutics Food ColloidEngineeringFunctional PropertyPolymer ScienceMicelle	2001	93
The stability of intravenous fat emulsions in total parenteral nutrition mixtures C. Washington International Journal of Pharmaceutics Food ColloidNutritionClinical NutritionIntravenous Fat EmulsionsPharmacology	1990	92
Propofol in an Emulsion of Long- and Medium-Chain Triglycerides: The Effect on Pain Jens Rau, Michael F. Roizen, Michael O’Connor, Anesthesia & Analgesia	2001	76
A.280 Reducing pain during propofol injection: role of the solvent Jens Rau, Michael F. Roizen British Journal of Anaesthesia Health SciencesPain MedicineMedicinePostoperative Pain ManagementPropofol Injection	1996	75
The effect of the addition of lignocaine on propofol emulsion stability E. Lilley, P. Isert, Melanie L. Carasso, Anaesthesia	1996	74

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