Human TNF mutants with selective activity on the p55 receptor

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

Barry J. Sugarman, Bharat B. Aggarwal, Philip E. Hass et al. · Science · 1985 · 1.6K citations

Apoptosis, Immune Regulation, Immunology +20

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

Louis A. Tartaglia, R F Weber, Irene S. Figari et al. · Proceedings of the National Academy of Sciences · 1991 · 813 citations · Full text

Human Tnf, Immunology, Immune Regulation +21

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

D Liénard, Patricia Ewalenko, Jean-Baptiste Delmotte et al. · Journal of Clinical Oncology · 1992 · 723 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

Manfred Brockhaus, Hans-Joachim Schoenfeld, E.-J. Schlaeǵer et al. · Proceedings of the National Academy of Sciences · 1990 · 665 citations · Full text

Immunology, Pathology, Cell Death +16

Recombinant tumor necrosis factor: its effect and its synergism with interferon-γ on a variety of normal and transformed human cell lines

Lucie Fransen, José Van der Heyden, Roos Ruysschaert et al. · European Journal of Cancer and Clinical Oncology · 1986 · 279 citations

Inflammation, Cytokine, Innate Immune System +11