Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

Matthias Grell, Eleni Douni, Harald Wajant et al. · Cell · 1995 · 1.3K citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

Pilar Garin‐Chesa, Lloyd J. Old, Wolfgang J. Rettig · Proceedings of the National Academy of Sciences · 1990 · 738 citations

Veterinary Medicine, Oncology, Pathology +17

In vivo molecular target assessment of matrix metalloproteinase inhibition

Christoph Bremer, Ching‐Hsuan Tung, Ralph Weissleder · Nature Medicine · 2001 · 731 citations

Medicine, Molecular Biology, Pharmacology +14

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

Horst Will, Susan J. Atkinson, Georgina S. Butler et al. · Journal of Biological Chemistry · 1996 · 565 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

Benjamin E. Turk, Lisa Huang, Elizabeth T. Piro et al. · Nature Biotechnology · 2001 · 562 citations

Life Sciences, Biochemistry, Molecular Biology +14