Fullerene Science and Technology · 1997 · 15 citations · 7 references
MedicineMedicinal ChemistryPharmacologyMolecular PharmacologyMolecular VirologyVirologyAntiretroviral TherapyAntiviral AgentsAntiviral PharmacologyAntiviral TherapyViral InfectionsViral ReplicationAntiretroviral InteractionsAntiretroviral ResponseAntiviral Drug MechanismsAntiviral Mechanisms Of ActionAntiviral Structure-activity RelationshipsHiv Antiretroviral TherapyPharmacodynamics Of Antiretroviral TherapyViral Replication Inhibitors
Abstract We have observed thai nonderivatized C60 (buckminsterfullerene) could inhibit the replication of simian immunodeficiency virus (SIV) in vitro and the activity of Moloney murine leukemia virus (M-MuLV) reverse transcriptase (RT) (IC50 ≈3 μM). This means that biological effects are exerted via a direct and active interaction of the C6o skeleton with other macromolecules.
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Suppression of mouse viraemia and retroviral disease by 3′-azido-3′-deoxythymidine
Ruth M. Ruprecht, Luke G. O'Brien, Lucia D. Rossoni et al. · Nature · 1986 · 244 citations