Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials

Panagiotis Kottaridis, Rosemary E. Gale, Marion E. Frew et al. · Blood · 2001 · 1.5K citations · Full text

Life Sciences, Genetics, Hematology +16

Acute Myeloid Leukemia

Bob Löwenberg, James R. Downing, Alan K. Burnett · New England Journal of Medicine · 1999 · 1.2K citations

Medicine, Oncology, Radiation Oncology +14

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

Susanne Schnittger, Claudia Schoch, Martin Dugas et al. · Blood · 2002 · 964 citations · Full text

Medicine, Hematology, Oncology +17

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

G. Gordon Steel, Michael Peckham · International Journal of Radiation Oncology*Biology*Physics · 1979 · 906 citations

Medicine, Oncology, Radiation Oncology +14

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.

Hitoshi Kiyoi, Tomoki Naoe, Yasuyuki Nakano et al. · PubMed · 1999 · 765 citations

Medicine, Genetics, Oncology +16