Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR

Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

Carol MacKintosh, Kenneth A. Beattie, Susanne Klumpp et al. · FEBS Letters · 1990 · 1.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR

Rie Nishiwaki‐Matsushima, Tetsuya Ohta, Shinji Nishiwaki et al. · Journal of Cancer Research and Clinical Oncology · 1992 · 807 citations · Full text

Medicine, Oncology, Toxicology +14

Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases.

Richard E. Honkanen, Jean Zwiller, Richard E. Moore et al. · Journal of Biological Chemistry · 1990 · 585 citations · Full text

Life Sciences, Biochemistry, Microbiology +13

Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver.

Tetsuya Ohta, Eisaburo Sueoka, Naoko Iida et al. · PubMed · 1994 · 290 citations

Pharmacy, Molecular Biology, Toxicology +16

The cyanobacterial toxin microcystin binds covalently to cysteine‐273 on protein phosphatase 1

Robert W. MacKintosh, Kevin N. Dalby, David G. Campbell et al. · FEBS Letters · 1995 · 287 citations · Full text

Life Sciences, Biochemistry, Toxicology +17