International Journal of Cosmetic Science · 2002 · 45 citations · 14 references
Life SciencesBiochemistryAnalytical ChemistryBioisosterismMass Spectrometric AnalysisLipidomicsMass SpectrometryCeramide ContentCeramide MetabolismHair BiomarkersHair Loss PathogenesisRadioactivity MeasurementSecondary Ion Mass Spectrometry
Repetitive hair-relaxing treatments often applied to African-American hair weaken the hair structure. Therefore hair breakage is a common feature of African-American hair and an important cause of hair loss. Recently, by analysing the lipids extracted from human hair, a fraction of free-ceramide was isolated in which sphinganine was predominant. This study shows that this sphinganine-derived ceramide (i.e. C18-dhCer) binds to African-American hair and protects it from weakening caused by chemicals. To show this binding, we used two methods: radioactivity detection with a microimager and secondary ion mass spectrometry. We evaluated the benefits of C18-dhCer on African-American hair fibre, relaxed by guanidine hydroxide, using a new method called the Break'in Brush Technique (BBT). This method determines the hair breakage resistance during a brushing. Using this technique, we have shown less breakage when applying a shampoo with ceramide. The present study opens new prospects for the development of products able to increase the protection, provide better care and meet the needs of African-American hair thanks to the effect of ceramide binding.
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Hair Density in African Americans
Leonard C. Sperling · Archives of Dermatology · 1999 · 137 citations
Medicine, Dermatology, Pathology +13
Diseases of the Hair and Scalp
Hodgins · British Journal of Dermatology · 1998 · 120 citations
Medicine, Dermatology, Pathology +10
Bernt Lindelöf · Archives of Dermatology · 1988 · 98 citations
Medicine, Anatomy, Dermatology +11