Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

James G. Herman, Adrian Merlo, Li Mao et al. · PubMed · 1995 · 1.4K citations

Medicine, Genetics, Oncology +17

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

Susan Goelz, Bert Vogelstein, Stanley R. Hamilton et al. · Science · 1985 · 838 citations

Medicine, Molecular Biology, Oncology +16

Molecular Cloning of Human Intestinal Mucin cDNAs

James R. Gum, J C Byrd, James W. Hicks et al. · Journal of Biological Chemistry · 1989 · 541 citations · Full text

Life Sciences, Molecular Biology, Oncology +12

Reduced genomic 5-methylcytosine content in human colonic neoplasia.

Andrew P. Feinberg, Charles W. Gehrke, Kenneth C. Kuo et al. · PubMed · 1988 · 490 citations

Medicine, Molecular Biology, Oncology +13

Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

Manel Esteller, Silvia Tórtola, M Toyota et al. · PubMed · 2000 · 470 citations

Medicine, Genetics, Oncology +17