Concepedia

RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT)

Michael J. Ashton, A. W. BRIDGE, Raymond C. Bush, DONALD I. DRON, Neil V. Harris, G.D. Jones, David J. Lythgoe, David Riddell, Christopher Smith

Bioorganic & Medicinal Chemistry Letters · 1992 · 27 citations · 2 references

Concepts

Life SciencesMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryEnzymologyCholesterol BiosynthesisCholesterol MetabolismEnzyme InhibitionFatty Acid BiosynthesisLipid Biosynthesis InhibitionAcyltransferase ActivityAcyltransferase EnzymesCholesterol EsterificationPharmacological Inhibition Of Cholesterol Biosynthesis

References

2

Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

Keith E. Suckling, Eduard F. Stange · Journal of Lipid Research · 1985 · 522 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Properties of acyl-CoA:cholesterol acyltransferase in rat liver microsomes. Topological localization and effects of detergents, albumin, and polar steroids.

Alice H. Lichtenstein, Peter Brecher · Journal of Biological Chemistry · 1980 · 111 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11