Double-stranded DNA stereoselectively binds benzo(a)pyrene diol epoxides

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Joyce McCann, E Choi, Edna N. Yamasaki et al. · Proceedings of the National Academy of Sciences · 1975 · 3.3K citations · Full text

Pharmacy, Environmental Sciences, Toxicology +16

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

Peter Sims, P.L. Grover, Alan Swaisland et al. · Nature · 1974 · 1.1K citations

Life Sciences, Biochemistry, Metabolism +12

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

P. Brookes, P.D. Lawley · Nature · 1964 · 678 citations

Pharmacy, Molecular Biology, Toxicology +17

Benzo[ <i>a</i> ]pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in Vitro and in Vivo

I. Bernard Weinstein, Alan M. Jeffrey, K. W. Jennette et al. · Science · 1976 · 580 citations

Life Sciences, Biochemistry, Molecular Biology +16

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

Eliezer Huberman, Leo Sachs, Shen K. Yang et al. · Proceedings of the National Academy of Sciences · 1976 · 480 citations · Full text

Pharmacy, Toxicology, Carcinogenesis +16