Isoxazolines‐Key Intermediates For Syntheses of Some Naturally Occuring Amino Compounds

Abstract

Abstract [3+2]‐Cycloaddition of nitrile oxides with alkenes, modification of isoxazoline intermediates, and subsequent cleavage give rise to a variety of functionalized acyclic structures. Each step may be used to diastereoselectively increase the number of chiral centres. Application of this concept to the synthesis of natural amino polyols, amino sugars and hydroxy amino acids is discussed.