Antiangiogenic Activity of Tumor Necrosis Factor-.ALPHA. Production Regulators Derived from Thalidomide.

Abstract

Recently, we developed novel tumor necrosis factor (TNF)-alpha production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.