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An immunoaffinity liquid chromatography–tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation

Endogenous Aggrecan FragmentsEngineeringMedicineBioanalysisImmunologyMass SpectrometryPathologyBiological Mass SpectrometryOsteoarthritisImmunochemistryAnalytical ChemistryBiomedical AnalysisAnalytical BiotechnologyAggrecanase ActivityCartilage DegradationChromatography