Concepedia

Autoimmune response to the spliceosome

W. Hassfeld, G Steiner, A Studnicka-Benke, Karl Skriner, W. Graninger, I. Fischer, Josef S. Smolen

Arthritis & Rheumatism · 1995 · 126 citations · 27 references

DOI

Abstract

Since both hnRNPs and snRNPs are essential components of the spliceosome, the data show that the immune systems of patients with RA, SLE, and MCTD react to this functional complex. However, compared with MCTD and SLE patients, RA patients have a more restricted immune response to the spliceosome: they react to hnRNP proteins, particularly to hnRNP-A2/RA33, but not to snRNPs.

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