5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases

Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency.

Chris H. Takimoto, Zhi Hong Lu, Ruiwen Zhang et al. · PubMed · 1996 · 167 citations

Medicine, Oncology, Pharmacology +13

A Rapid and Inexpensive Method for Anticipating Severe Toxicity to Fluorouracil and Fluorouracil-based Chemotherapy

Joseph Ciccolini, Cédric Mercier, Alexandre Evrard et al. · Therapeutic Drug Monitoring · 2006 · 83 citations

Pharmacy, Oncology, Pharmacology +17

DPD-based adaptive dosing of 5-FU in patients with head and neck cancer: impact on treatment efficacy and toxicity

Chen Yang, Joseph Ciccolini, Aurore Blesius et al. · Cancer Chemotherapy and Pharmacology · 2010 · 77 citations

Medicine, Oncology, Pharmacology +16

Severe Toxicity Related to the 5-Fluorouracil/Leucovorin Combination (The Mayo Clinic Regimen)

Medy Tsalic, Gil Bar‐Sela, Alex Beny et al. · American Journal of Clinical Oncology · 2003 · 72 citations

Medicine, Oncology, Pharmacology +17

Thiamin status of patients treated with drug combinations containing 5-fluorouracil

Meral Aksoy, Tapan K. Basu, Judith Brient et al. · European Journal of Cancer (1965) · 1980 · 56 citations

Medicine, Pharmacology, Pharmacotherapy +8