Common Strategy for Adult and Pediatric Medulloblastoma: A Multicenter Series of 253 Adults

Laëtitia Padovani, Marie‐Pierre Sunyach, David Pérol, +12

International Journal of Radiation Oncology*Biology*Physics

Neuro-oncologyPediatric Brain TumorsPediatric NeurosurgerySurgical PathologyCommon Strategy +5

Cytidine Deaminase Residual Activity in Serum Is a Predictive Marker of Early Severe Toxicities in Adults After Gemcitabine-Based Chemotherapies

Joseph Ciccolini, Laëtitia Dahan, Nicolás André, +13

Journal of Clinical Oncology

Cda DeficiencyGemcitabine-based ChemotherapiesPathologyPharmacotherapyToxicology +14

A Rapid and Inexpensive Method for Anticipating Severe Toxicity to Fluorouracil and Fluorouracil-based Chemotherapy

Joseph Ciccolini, Cédric Mercier, Alexandre Evrard, +11

Therapeutic Drug Monitoring

Oral CapecitabineCancer ManagementCapecitabine IntakePathologyPharmacotherapy +16

A simple and rapid high-performance liquid chromatographic (HPLC) method for 5-fluorouracil (5-FU) assay in plasma and possible detection of patients with impaired dihydropyrimidine dehydrogenase (DPD) activity

Joseph Ciccolini, Cédric Mercier, M.F Blachon, +3

Journal of Clinical Pharmacy and Therapeutics

DPD-based adaptive dosing of 5-FU in patients with head and neck cancer: impact on treatment efficacy and toxicity

Chen Yang, Joseph Ciccolini, Aurore Blesius, +15

Cancer Chemotherapy and Pharmacology

Dpd-based Adaptive DosingNeck CancerOncologyMedicineTreatment Efficacy +6

High-dose methotrexate in adults with osteosarcoma: a population pharmacokinetics study and validation of a new limited sampling strategy

Charlotte Dupuis, Cédric Mercier, Chenguang Yang, +10

Anti-Cancer Drugs

PharmacotherapyMetronomic ChemotherapyPharmacodynamic ModelingPre-clinical PharmacologySystems Pharmacology +19

Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation

Cédric Mercier, Caroline Raynal, Laëtitia Dahan, +12

Pharmacogenetics and Genomics

5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases

Pierre‐Yves Cordier, A. Nau, Joseph Ciccolini, +4

Cancer Chemotherapy and Pharmacology

Neurodegenerative DiseasesPathologyDegenerative DiseaseNeuroprotectionNeurology +5

Early severe toxicities after capecitabine intake: possible implication of a cytidine deaminase extensive metabolizer profile

Cédric Mercier, Charlotte Dupuis, Aurore Blesius, +8

Cancer Chemotherapy and Pharmacology

MedicineCapecitabine IntakeSevere ToxicitiesPoisoningToxicology +7

Toxic death-case after capecitabine + oxaliplatin (XELOX) administration: probable implication of dihydropyrimidine deshydrogenase deficiency

Joseph Ciccolini, Cédric Mercier, Laëtitia Dahan, +8

Cancer Chemotherapy and Pharmacology

Dihydropyrimidine Deshydrogenase DeficiencyMedicinePathologyPoisoningProbable Implication +6