Methylglyoxal induces DNA crosslinks in ECV304 cells via a reactive oxygen species-independent protein carbonylation pathway

Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

Theodore W. C. Lo, Marie Westwood, Antony C. McLellan et al. · Journal of Biological Chemistry · 1994 · 695 citations · Full text

Life Sciences, Biochemistry, Enzymology +11

Covalent Modification of Amino Acid Nucleophiles by the Lipid Peroxidation Products 4-Hydroxy-2-nonenal and 4-Oxo-2-nonenal

Jonathan A. Doorn, Dennis R. Petersen · Chemical Research in Toxicology · 2002 · 297 citations

Life Sciences, Biochemistry, Molecular Biology +17

Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase

David L. Vander Jagt, Lucy A. Hunsaker · Chemico-Biological Interactions · 2003 · 254 citations

Life Sciences, Biochemistry, Endocrinology +17

Methylglyoxal Impairs the Insulin Signaling Pathways Independently of the Formation of Intracellular Reactive Oxygen Species

Audrey Riboulet-Chavey, Anne Pierron, Isabelle Durand et al. · Diabetes · 2006 · 223 citations · Full text

Life Sciences, Biochemistry, Endocrinology +15

Determination of toxic carbonyl compounds in cigarette smoke

Kazutoshi Fujioka, Takayuki Shibamoto · Environmental Toxicology · 2006 · 194 citations · Full text

Pharmacy, Chemistry, Toxicology +11