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Differential Role for CD80 and CD86 in the Regulation of the Innate Immune Response in Murine Polymicrobial Sepsis

DOIFull Paper Access

125

Citations

28

References

2009

Year

Anna Nolan, Hiroshi Kobayashi, Bushra Naveed, Ann Marie Kelly, Yoshihiko Hoshino, Satomi Hoshino, Matthew Karulf, William N. Rom, Michael D. Weiden, Jeffrey A. Gold
PLoS ONE

Abstract

In conclusion, our data describe a differential role for CD80 and CD86 in regulation of inflammation in the innate immune response to sepsis. Future therapeutic strategies for blockade of the CD80/86 system in sepsis should focus on direct inhibition of CD80.

References

YearCitations

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