LIFE-SUPPORTING HUMAN COMPLEMENT REGULATOR DECAY ACCELERATING FACTOR TRANSGENIC PIG LIVER XENOGRAFT MAINTAINS THE METABOLIC FUNCTION AND COAGULATION IN THE NONHUMAN PRIMATE FOR UP TO 8 DAYS1

Abstract

The livers from h-DAF transgenic pigs did not undergo hyperacute rejection after orthotopic xenotransplantation in baboons. When HAR is abrogated, the porcine liver maintains sufficient coagulation and protein levels in the baboon up to 8 days after OLT.