SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells

Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

Kevin Pruitt, Rebekah L. Zinn, Joyce E. Ohm et al. · PLoS Genetics · 2006 · 381 citations · Full text

Histone Modifications, Epigenetic Change, Genetics +18

Melatonin Promotes Osteoblast Differentiation and Bone Formation

Jerome A. Roth, Byung‐Gook Kim, Wen‐Lang Lin et al. · Journal of Biological Chemistry · 1999 · 342 citations · Full text

Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model

Brittney Jung‐Hynes, Travis L. Schmit, Shannon Reagan‐Shaw et al. · Journal of Pineal Research · 2010 · 155 citations

Circadian Rhythm, Urology, Sirt1 Inhibition +13

Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway

Sara C. Zapico, Jezabel Rodríguez‐Blanco, Guillermo García‐Santos et al. · Journal of Pineal Research · 2009 · 126 citations · Full text

Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways

Ning Kang, Jinghai Zhang, Feng Qiu et al. · Cancer Letters · 2010 · 126 citations

Oxidative Stress Coincident, Medicine, Apoptosis +11