Angewandte Chemie International Edition · 2008 · 59 citations · 34 references
Life SciencesBiochemistryImmunologyBiosensorsMass Spectrometric AnalysisProteomicsAntigen Detection AssaysBiosensors For Immune DetectionMass SpectrometryMass Spectrometry-based ProteomicsAmplificationImmunoassay InstrumentationMatrix-assisted Laser Desorption Ionization Time-of-flight Mass SpectrometryMatrix-assisted Laser Desorption/ionization Time-of-flight Mass SpectrometryMethod Detection LimitMonolayersSelf-assembled MonolayersUltrasensitive Detection
Small but more than enough: Proteins are detected in solution without additional amplification or labeling steps by using a small molecule as a reporter of the protein (see picture, Am-tag=amplification tag). The combination of self-assembled monolayers on gold with matrix-free laser desorption/ionization time-of-flight mass spectrometry offers ultrahigh sensitivity with a detection limit of several attomoles.
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