Low Dose Cranial Irradiation-Induced Cerebrovascular Damage Is Reversible in Mice

Abstract

Not only high but low and moderate doses of cranial irradiation increase permeability of cerebral vessels in mice, but this effect is reversible by 6 months. In-vitro experiments suggest that irradiation changes junctional morphology, decreases cell number and causes senescence in brain endothelial cells.