Biotransformation of Nobiletin by <i>Aspergillus </i><i>n</i><i>iger </i>and the Antimutagenic Activity of a Metabolite, 4‘-Hydroxy-5,6,7,8,3‘-pentamethoxyflavone

Abstract

Biotransformation of nobiletin (1) by Aspergillus niger has been investigated, and the product obtained was determined as 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (2). Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ, and Trp-P-1.