A multicellular 3D heterospheroid model of liver tumor and stromal cells in collagen gel for anti-cancer drug testing

The price of innovation: new estimates of drug development costs

Joseph A. DiMasi, Ronald W. Hansen, Henry G. Grabowski · Journal of Health Economics · 2003 · 4.3K citations · Full text

Pharmacy, Pharmaceutical Policy, Pharmacoeconomics +14

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

Jörg Schrader, Timothy T. Gordon‐Walker, Rebecca L. Aucott et al. · Hepatology · 2010 · 735 citations · Full text

Medicine, Bioengineering, Oncology +17

Monolayer and Spheroid Culture of Human Liver Hepatocellular Carcinoma Cell Line Cells Demonstrate Distinct Global Gene Expression Patterns and Functional Phenotypes

Tammy T. Chang, Millie Hughes‐Fulford · Tissue Engineering Part A · 2008 · 310 citations

Life Sciences, Cell Biology, Molecular Biology +17

Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model

Sau Fung Wong, Da Yoon No, Yoon Young Choi et al. · Biomaterials · 2011 · 176 citations

Engineering, Bioengineering, Biomedical Engineering +11

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function #

Colleen M. Brophy, Jennifer L. Luebke-Wheeler, Bruce Amiot et al. · Hepatology · 2008 · 150 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16