5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

Maria Dorota Majewska, Neil L. Harrison, Rochelle D. Schwartz et al. · Science · 1986 · 2.2K citations

Medicine, Neuroscience, Pharmacology +17

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

Neil L. Harrison, Monika Majewska, J W Harrington et al. · Journal of Pharmacology and Experimental Therapeutics · 1987 · 615 citations

Life Sciences, Neuroscience, Pharmacology +17

Anxiolytic activity of an endogenous adrenal steroid

Jacqueline N. Crawley, John R. Glowa, Maria Dorota Majewska et al. · Brain Research · 1986 · 320 citations

Life Sciences, Endocrinology, Pharmacology +14

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency

A. Leslie Morrow, Peter D. Suzdak, Steven M. Paul · European Journal of Pharmacology · 1987 · 295 citations

Life Sciences, Biochemistry, Pharmacology +14

Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates.

D M Turner, Richard W. Ransom, Jay Yang et al. · Journal of Pharmacology and Experimental Therapeutics · 1989 · 276 citations

Medicine, Neuroscience, Pharmacology +17