Publication | Closed Access
One-pot Deprotection and Coupling of Peptides by the Fmoc Strategy
27
Citations
8
References
1993
Year
BiochemistryNatural SciencesMedicinePeptide LibraryBioconjugationFmoc StrategyFluorous SynthesisPeptide TherapeuticPeptide SynthesisOrganic ChemistryPeptide ScienceProtein EngineeringPeptide EngineeringChemistryAbstract 9-FluorenylmethyloxycarbonylBiomolecular EngineeringDrug DiscoveryTetrabutylammonium Fluoride Hydrate
Abstract 9-Fluorenylmethyloxycarbonyl (Fmoc) group can be quickly removed with tetrabutylammonium fluoride hydrate (TBAF·xH2O) in the presence of a large excess of phenylmethanethiol or 1-octanethiol. Subsequent oxidation of the thiol with bis(1-methyl-1H-tetrazol-5-yl) disulfide simultaneously inactivated the TBAF and enabled one-pot peptide bond elongation by the Fmoc strategy.
| Year | Citations | |
|---|---|---|
Page 1
Page 1